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Dose Response Relationship in Anti-Stress Gene Regulatory Networks

Figure 5

Effect of Saturation of Gene Activation on Systems-Level Gains and Dose Response Curves

Saturation of gene activation was modeled by implementing saturable T binding to the gene promoter.

(A) In the presence of saturation of gene activation, the lnY versus lnS curve transitions from a linear function lnY = lnS + lny₁ to lnY = lnS + lny₂.

(B) Systems-level gain (dash-dotted line) increases from to asymptotically approach unity. The Y versus S curve (solid line) transitions from a superlinear function , through a sublinear segment, to a linear function Y = y₂S.

(C) Systems-level gain (dash-dotted line) decreases from the maximum to asymptotically approach zero. The G versus S curve (solid line) transitions from a function to a horizontal line G = g₂.

doi: https://doi.org/10.1371/journal.pcbi.0030024.g005