< Back to Article
Dose Response Relationship in Anti-Stress Gene Regulatory Networks
Figure 4
Effect of Constitutive Activation on Systems-Level Gains and Dose Response Curves
Constitutive activation was modeled by implementing a basal-level expression of G in addition to T-driven expression.
(A) The lnY versus lnS curve transitions from a linear function lnY = lnS + lny0 to lnY =
lnS + lny1 in the presence of constitutive activation.
(B) In the presence of constitutive activation, systems-level gain
(dash-dotted line) decreases from unity to asymptotically approach
; in the absence of constitutive activation,
remains at
(unpublished data). Y responds to S in a more sensitive or less controlled manner in the presence of constitutive activation (solid line) than in its absence (dotted line).
(C) In the presence of constitutive activation, systems-level gain
(dash-dotted line) increases from zero to asymptotically approach a maximum
; in the absence of constitutive activation,
remains at
(unpublished data). G responds to S in a more sluggish manner in the presence of constitutive activation (solid line) than in its absence (dotted line).
doi: https://doi.org/10.1371/journal.pcbi.0030024.g004