Dose Response Relationship in Anti-Stress Gene Regulatory Networks
Figure 3
Effects of Local Gains on Shape of Dose Response Curves in the Anti-Stress Gene Regulatory Network in Figure 2
(A) Enhancing local gain r1 through dimerization or trimerization of transcription factor T increases the superlinearity of Y versus S dose response curve, decreases the superlinearity of T versus S and G versus S dose response curves.
(B) Enhancing local gain r2 through T cooperative binding to the gene promoter or tetramerization of gene product G increases the superlinearity of Y versus S and T versus S dose response curves, decreases the superlinearity of G versus S dose response curve.
(C) Effects of combinatorial changes in r1 and r2; green line (r1 = 2, r2 = 4), blue line (r1 = 2, r2 = 2×1.5); note that high loop gains tend to linearize the G versus S dose response curve.
Default local gains: r1 = r2 = −r3 = 1. Solid line, simulation results; symbol, analytical results using Equations 8-10.