Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein–Coupled Receptor Signaling
Figure 5
The Effect of the Ratio of Receptor to G Protein on G Protein Activation
Rtotal was set at 5,000/cell and Gtotal varied (dashed line). As G protein expression increases, the response changes from negative to positive agonism. Gtotal was set at 100,000 per cell and Rtotal varied (solid line). As receptor expression increases, the response changes from negative to positive agonism.