Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Figure 9
Average VEGF Signaling for the 48 Hours Following Treatment Inhibition Is Decreased at Higher Microvascular Density
The gray lines represent the case of 2% vascular volume (as depicted in Figure 4); the colored lines represent a 4.2% vascular volume. The peak inhibition due to the blockade of VEGFR–Neuropilin coupling is the same for both vascular densities; however, the peak for the other two treatments is lower. Endothelial cells expressing 10,000 VEGFR2 and 100,000 Neuropilin-1.