Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Figure 8
VEGF Signaling Inhibition Is Effective for a Shorter Period of Time for a Tissue with a Higher Microvascular Density
(A–C) VEGF–VEGFR2 complex formation on the endothelial cells following each of the three treatments. The tumor modeled here expresses 10,000 VEGFR2 and 100,000 Neuropilin per endothelial cell. Gray lines represent the case of 2% vascular volume, as depicted in Figure 3; the black lines represent 4.2% vascular volume. Note that while the 103/cell, pM, and nM scales apply to both the gray and black lines, the pmol/L tissue scales apply only to the black lines; the normalization is different for the gray lines (see Figure 3 for the correct scales).
(D–F) Free (unbound) VEGF concentration in the interstitial space. *VEGF121 secreted at the same rate as VEGF165.
(G–I) The concentration of VEGF inhibitor in the interstitial space, or density of Neuropilin on the blood vessel endothelial cell surface.