Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Figure 5
Tissue Expressing High VEGFR1 Levels Responds Differently to Treatment
(A–C) Formation of VEGF–VEGFR2 complexes over time following anti-Neuropilin treatment, for a tumor expressing 10,000 VEGFR1 per endothelial cell in addition to the VEGFR2 and Neuropilin-1 expression of Figures 3 and 4.
(D–F) VEGF–VEGFR1 complex formation.
(G–I) Free (unbound) interstitial VEGF concentration. *VEGF121 secreted at the same rate as VEGF165.