Targeting Neuropilin-1 to Inhibit VEGF Signaling in Cancer: Comparison of Therapeutic Approaches
Figure 4
Average VEGF–VEGFR2 Signaling Inhibition
The average inhibition of VEGF–VEGFR2 complex formation over the 48 hours following blockade of Neuropilin-1 expression (A), or bolus intratissue protein delivery (B) of competitive binding inhibitor or VEGFR–Neuropilin-1 coupling blocker. Endothelial cells expressing 10,000 VEGFR2 and 100,000 Neuropilin-1.