Computational Model Explains High Activity and Rapid Cycling of Rho GTPases within Protein Complexes
Figure 6
Comparison of the Complete and Reduced Models for the GEF–GAP Cycling Control Module
The Euclidean distance between the flux vectors of complete and reduced models was computed as described in Methods and normalized by the magnitude of the flux vector for the complete model. The profile of the normalized distance is shown by thick solid contour lines. The profile of the performance index P (same as Figure 3C) is shown by a thin line for comparison. Note that in the parameter region where the GTPase cycles with a high activity and turnover rate, the difference between the complete and reduced models is 5% or less.