Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
Figure 6
Comparison with Previous CIS Definition
(A) Plot of the increase of the error as a function of the screen size, when using the definition from [8], computed using the Poisson distribution, or a permutation approach. Also the results from the two individual windows used are given. Since the errors made by the two windows individually are not mutually exclusive, the Poisson estimate is an overestimate of the true error.
(B) Venn diagram comparing three different CIS definitions: a) the definition from [8] applied to the complete dataset, b) the csCISs resulting from the GKC, and c) the published CISs from the RTCGD. The intersection between sets shows three counts (and corresponding percentages), indicating the count for set a, b, and c, respectively. This is because the three sets of CISs used different definitions (at different scales) for a CIS, so that some CISs are split up, and hence are counted twice.