Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
Figure 1
Schematic View of Insertion Data
(A) Schematic view of the mapped data of four tumors. Significance is determined by the number of tumors which contain insertions in a particular region. The geometric symbols represent the insertions and are given a different shape for each tumor. The blue regions indicate possible CISs.
(B) When considering a broad region, the number of insertions one would expect to have occurred by chance is higher, and hence the regions need to be hit in more independent tumors than for narrow regions before significance is reached.
(C) Genes (indicated by the green bars) may be affected from various loci around or within the gene, and there does not exist one distance over which viral inserts act on their targets.