Meta-Analysis of Differentiating Mouse Embryonic Stem Cell Gene Expression Kinetics Reveals Early Change of a Small Gene Set
Figure 3
Two-way Pareto Front Analysis applied to CVs from the R1–LR Dataset and the M–LR Dataset
(Left) Shows the CVs for all comparable genes with the first five Pareto fronts highlighted (red, first PF; blue, second PF; green, third PF; gold, fourth PF; black, fifth PF).
(Right) Shows a magnification of the dashed box in the left panel. Here the red gene is said to dominate all other genes because, although it has an M–LR CV equal to that of several other genes, it has the highest R1–LR CV. Thus it lies on the first PF. In the same way, the blue gene dominates all genes except the red gene and thus lies on the second PF. It is not possible to choose between the two green genes because they each have larger CVs in one of the two experiments. They, therefore, lie on the same (third) PF. The highlighted yellow gene does have a larger CV in the R1–LR dataset than the green gene on the left but it falls on a lower PF because it is completely dominated by the green gene on the right.