Structural Modeling of Protein Interactions by Analogy: Application to PSD-95
Figure 4
The Localization of Binding Sites for Both Modeled Configurations of the PDZ3–SH3–GK Core Fragment Compared with Protein Docking
Top ten scoring models were selected for both interactions (PDZ3–SH3, PDZ3–GK) obtained using comparative patch analysis and using conventional protein docking. The localization index δI of a residue defines the relative frequency of its participation in the interaction interface. The residues that are colored grey do not participate in the interface of any of the top ten models. The PRBS in SH3 and the GBS in GK are shown by arrows.