The Role of Compensatory Mutations in the Emergence of Drug Resistance
Figure 7
Years until Emergence Occurs as a Function of Treatment
(A) All conversion probabilities are μi = 10−3. The green dashed line shows a situation with two resistant strains with fitness 60% and 90% that of the sensitive strain. The blue dash-dotted line shows three resistant strains with fitness 60%, 75%, and 90%, and the red solid line shows four resistant strains with fitness 60%, 70%, 80%, and 90%.
(B) Same number of strains and fitness levels as (A) but the product of all conversion probabilities is kept the same. We choose μt = 10−2 for all three cases and μ1 = 10−6 for the two-strain scenario (dashed green line), μ1 = μ2 = 10−3 for the three-strain scenario (dash-dotted blue line), and μ1 = μ2 = μ3 = 10−2 for the four-strain scenario (solid red line).
(C) Three resistant strains with fitness of 60%, 75%, and 90%. Conversion rates are μi = 10−1 (dashed green line), μi = 10−2 (dash-dotted blue line), and μi = 10−3 (solid red line).
(D) Same as (C) but with conversion rates μt = 10−2, μ1 = μ2 = 10−3 (dashed green line), μt = 10−4, μ1 = μ2 = 10−2 (dash-dotted blue line), and μt = μ2 = 10−3, μ1 = 10−2 (solid red line).