The Role of Compensatory Mutations in the Emergence of Drug Resistance
Figure 3
Number of Introductions Q = μt Ît per Year
Parameter choices are described in the text and in Table 1. Note that above a certain level of treatment, indicated by f*, the basic reproductive number for the sensitive strain is , which makes the endemic steady state unsustainable and leads to disease extinction. In this study, we only consider the endemic situation with 0 ≤ f < f*.