Phylogenetic Reconstruction of Orthology, Paralogy, and Conserved Synteny for Dog and Human
Figure 8
Dotplot of PhyOP Orthologues Showing Conserved Synteny in the Dog and Human Chromosomes
(A) Synteny between CFAX and HSAX.
(B) Synteny between CFA9 and HSA17.
Genes are plotted in consecutive gene order along each chromosome. The two X chromosomes are in a single conserved syntenic block. However, known human-specific paralogues of SSX, MAGE, opsin, and TEX28 families have been highlighted. The sequence containing the opsin and TEX28 families is highly polymorphic in the human population [65]. The human X chromosome genome sequence contains two copies of the green-cone photoreceptor pigment gene in the opsin family interdigitated with three full-length copies of TEX 28. The plot of orthologous gene positions between CFA9 and HSA17 recapitulates known syntenic rearrangements in the human lineage [6].