Phylogenetic Reconstruction of Orthology, Paralogy, and Conserved Synteny for Dog and Human
Figure 6
PhyOP, Ensembl, and Inparanoid dS Cumulative Frequency Distributions
These include orthologues which have (manys) or have not (1:1) been involved in lineage specific duplications. The dS distributions for 1:1 orthologues are similar for the three methods. The distributions for Ensembl and Inparanoid 1:1 orthologues are indistinguishable, and the median dS for PhyOP 1:1 orthologues is only slightly smaller. This is mainly because most of the predictions are common to all. PhyOP “manys” orthologues have a larger median dS than do 1:1 orthologues. The dS distributions for “manys” orthologues predicted by Inparanoid and Ensembl are very much shifted to the right, indicating that a large proportion of these genes may have diverged well before the dog and human lineages separated.