Transcriptional Dynamics of the Embryonic Stem Cell Switch
Figure 2
Putative Network Motifs Related to the System of OCT4, SOX2, and NANOG
The motif in (A) captures the regulatory interactions of the system at the gene–gene level. Because (A) was not observed in any of the databases for lower organisms (see text), we searched for the same subgraph without autoregulations (B), followed by its two-gene counterpart with positive regulation (C). Finally, one of the activations was replaced with two repressions in series, yielding (D). A small number of instances of (C) and (D) were found in the databases (see text).