Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome

Figure 8

Consequences of Excessively Stabilizing CI2

(A) Histograms of folding times obtained from refolding and de novo folding trajectories of CI2 with ɛ = 0.80 kcal/mol.

(B) Snapshot of a “trapped” trajectory.

(C) Plots of Q versus time for ten previously trapped trajectories when restarted without the ribosome.

(D) Same as (C), but restarted with the ribosome and ɛ = 0.60 kcal/mol.