Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
Figure 7
Simulated Mechanisms of Refolding and De Novo Folding for CI2 and Barnase
(A) Comparison of computed and experimental Φ values for CI2.
(B) Same as (A), but for for barnase.
(C) Plot of Qres versus Q for refolding of CI2.
(D) Same as (C), but for refolding of barnase.
(E) Same as (C), but for the post-synthesis stage of de novo folding of CI2.
(F) Same as (C), but for the post-synthesis stage of de novo folding of barnase.
In panels (C–F), Qres values are shown on a continuous color scale between 0.0 (blue) and 0.75 (red) for CI2, and between 0.0 (blue) and 0.9 (red) for barnase.