Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
Figure 4
Fifty Coupled Synthesis–Folding Simulations of CI2
(A) Snapshots showing all 50 coupled synthesis–folding simulations of CI2 at the moment at which the final residue is released.
(B) and (C) Snapshots for the same system at the moment that the native conformations are achieved; the two views are related by a 90° rotation around the vertical axis. Note that in this simulation model, the proteins do not diffuse far from the ribosome before completing folding.