Molecular Simulations of Cotranslational Protein Folding: Fragment Stabilities, Folding Cooperativity, and Trapping in the Ribosome
Figure 2
Folding Free Energy Surfaces for CI2 Fragments
(A–D) Free energy surfaces for fragments comprising residues 1–40, 1–50, 1–60, and 1–64 (full length), respectively. Free energy (G) is shown on a continuous color scale from 0 (red) to +5 kcal/mol (white); symbols show the mean value of Q in 5-K intervals. Cartoons in bottom-left corner of each panel indicate the “native” structure of each fragment generated using RasMol [94].