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Wiggle—Predicting Functionally Flexible Regions from Primary Sequence

Figure 7

Wiggle Predictors Identify Important FFR in PVUII Endonuclease

(A) Plot of FF scores and mapping of values in a gradient code from negative (blue) to positive (red) onto the structure of PVUII endonuclease in complex with DNA (yellow). The following structural features are labeled: (1) minor groove binding loop, (2) catalytic loop, (3) potential hinge for DNA binding, (4) tyrosine 94 for Mg++ ion coordination, and (5) major groove binding loop. (PDB ID: 3PVI).

(B) Wiggle predictions (solid line) are mapped in green and Wiggle200 predictions (dashed line) are mapped in orange onto the structure.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.0020090.g007