Wiggle—Predicting Functionally Flexible Regions from Primary Sequence
Figure 6
Performance of Wiggle Predictors on Arc Repressor
(A) The dimer conformation of the Arc repressor was used to model global fluctuation. Using the FFR definition, the plot for a single chain is shown on the left with structural mapping of values onto a dimer on the right. FF scores are mapped with the gradient code from negative (blue) to positive (red). Only the C-terminal tail exceeds threshold lines (red) and is defined as an FFR while the rest of the protein is not. (PDB ID: 1BAZ)
(B) The hinge between the two helices is identified by predictors as well as N-terminal residues important for DNA recognition. Predictions from Wiggle (solid line) are mapped in green on the structure and Wiggle200 (dashed line) are mapped in orange.