Extracting Gene Networks for Low-Dose Radiation Using Graph Theoretical Algorithms
Figure 7
Differential Correlation Identifies Edges Impacted by IR
The graph was filtered to identify edges that exceeded r = |0.875| in one condition but were less than |0.25| in the other. Vertices with > 8 differential correlations are represented in (A). Red indicates edges that are present only in IR, while blue edges are only found in control. Dark edges for each color represent the subset of edges that are differentially correlated and of opposite direction (+ vs. −) in the two conditions, while bright edges are of the same direction. The portion of the graph containing three connected sub-graphs centered around Top3a, Notch3, and an unannotated gene is shown in (B).