Single-Molecule Dynamics Reveals Cooperative Binding-Folding in Protein Recognition
Figure 3
Illustration of Flexible Binding-Folding through Two-Dimensional Free-Energy Landscape, Trajectory and Time Correlation
(A) Flexible binding-folding.
(B) Two-dimensional free-energy contour plots of the interface degree of freedom between CBD portion of WASP and Cdc42, and conformation/folding degree of freedom for CBD.
(C) Typical trajectory of fraction of native contacts of binding interface between CBD portion of WASP and Cdc42.
(D) Time correlation function of fraction of native interface contacts.