Identification of Genome-Scale Metabolic Network Models Using Experimentally Measured Flux Profiles
Figure 3
Correspondence between Bottleneck Reactions Identified by the OMNI Approach and Gene Expression Changes in the Evolved Knockout Strains Relative to the Wild-Type E. coli Strain
Expression changes, reported as log2 ratios and statistically significant expression changes (see Materials and Methods for details) in each evolved strain, are shown by +/− signs depending on the direction of the change. The reaction names are listed in the first column and the corresponding genes are listed in the second column. The genes corresponding to the best combination of reaction bottlenecks of up to three reactions identified by the OMNI approach (Table 3) for each strain are shown by white boxes.