A Community Resource Benchmarking Predictions of Peptide Binding to MHC-I Molecules
Figure 2
ARB, SMM, and ANN Predictions for HLA-A*0201
The first three panels depict scatter plots of the predicted binding scores (x-axis) against the measured (y-axis) binding affinities of 3,089 9-mer peptides to HLA-A*0201. The predictions were obtained in five-fold cross-validation using the ARB/SMM/ANN prediction methods, respectively. In each plot, a linear regression on a logarithmic scale was performed, and the corresponding regression equation and r2 values are given. The bottom right panel contains an ROC analysis of the same data, evaluating how well the three methods can classify peptides into binders (IC50 < 500 nM) and nonbinders. The AUC, which evaluates prediction quality, is given for each method.