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How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?

Figure 4

Cross-Reactivity Can Lower the Loss of Memory if There Is Competition

We plot the effect of changing the average cross-reactivity on the decline in memory per exposure to a new pathogen in the presence and absence (□) of competition between the expansion of naive and memory cells described by Equation 6. Symbols represent the results obtained by computer simulations (for the introduction of 100 pathogens) and lines represent the analytical approximation as described in the text. Parameters are as in Figure 2B and 2C (absence and presence of competition).

doi: https://doi.org/10.1371/journal.pcbi.0020055.g004