How Does Cross-Reactive Stimulation Affect the Longevity of CD8+ T Cell Memory?
Figure 3
Analytic Approximations for the Average Decline in Memory
We plot the average change in memory lineages (defined by Equation 7) following exposure to a pathogen. The change in memory is proportional to Mj, the number of memory cells of new specificities generated by the pathogen (A); and inversely proportional to Ŷ, the total size of the memory compartment (B). The simulations for all the cases considered in the Results section were indistinguishable from the lines shown and are thus not explicitly plotted. Parameters: Same as previously, with Ŷ = 2 · 107 in (A) and Mj = 2 · 105 in (B).