Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays
Figure 1
The Elements Included in the HMM for LOH Inference
Unobserved LOH states (LOSS or RET) of SNP markers generate observed genotype calls via emission probabilities. The solid arrows indicate the transition probabilities between LOH states, and the dashed arrows indicate LD-induced dependencies between consecutive SNP genotypes.