Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation
Figure 5
The 20 lowest-energy loops predicted for (A) reconstruction of residues 152–163 in phosphorylated, cyclin-bound CDK2; and (B) prediction of the structure of residues 152–163 upon in silico phosphorylation of Thr160 in the unphosphorylated, cyclin-bound CDK2. In each case, the loop and surrounding side chains are optimized simultaneously as described in Materials and Methods.