Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation
Figure 3
Loop Reconstruction and Prediction in CDK2/Cyclin A
(A) Reconstruction: Crystal structure of phosphorylated CDK2/cyclin A (blue) and the predicted loop structure (red). The starting structure for the prediction was the phosphorylated structure, with the only difference being the loop region.
(B) Prediction: Crystal structure of phosphorylated CDK2/cyclin A (blue), the crystal structure of the unphosphorylated CDK2/cyclin A (green), and the predicted loop structure upon in silico phosphorylation of the unphosphorylated CDK2/cyclin A structure (red). Figures prepared with Chimera [72].