The Fragile Breakage versus Random Breakage Models of Chromosome Evolution
Figure 7
Breakpoint Reuse Rates as a Function of Upstream Regulatory Region Size in Intergenic Breakage Model Simulations
Genes from NCBI Human version 34 were each extended by length 0 to 210 kb upstream, thus shortening or eliminating the intergenic regions. In the intergenic breakage model, simulated reversals were performed with breakpoints chosen uniformly among the nucleotides remaining in the shortened intergenic regions, while in the random breakage model, breakpoints were chosen uniformly among all nucleotides in the genome. Then blocks were derived, and the breakpoint reuse rate was computed.