Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays
Figure 3
Counts of RNA Binding Motifs in Intron Sequences adjacent to Brain-Regulated Exons
The 100 base pairs upstream and downstream regions for constitutive exons (control), preferentially brain-included (brain include), and preferentially brain-skipped exons (brain skip) were evaluated for the presence of sequences related to binding sites for known splicing regulators. Sequences used as the consensus binding sites were Nova: UCAUU or UCAUC; Fox-1: GCAUG; PTB/nPTB: CUCUCU; hnRNP-H/F: GGGGG; and hnRNP A1: UAGGG.