Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays
Figure 2
Conservation of Cassette Exons Preferentially Included in Brain
(A) Extreme conservation in flanking intronic sequences of Baiap1 cassette exon seen in University of California Santa Cruz genome browser.
(B) Median conservation probability at each base 100 base pairs upstream (left) and downstream (right) of the exon for 36 brain-included exons (gray circles), 36 brain-skipped exons (hollow gray squares), about 1,000 skipped mouse exons conserved and alternatively spliced in both human and mouse (gray triangles), and about 47,000 constitutive mouse exons (black circles). These last two sets of exons are from an EST/mRNA-based study [24].
(C) Histograms of the median probability of conservation per 100 base pairs upstream and downstream of the brain preferentially included (light gray), constitutive exons (black), and overlapping regions (dark gray).