Signal Processing in the TGF-β Superfamily Ligand-Receptor Network
Figure 6
Control of the Kinetic Signaling Behavior
A key control quantity of the qualitative behavior of the system is the CIR. Panels on the left (A, C, and E) show the typical behavior of the system for different CIR values. The TGF-β concentration is increased at time 0 to saturating values and remains constant afterward, (A) inset. Panels on the right (B, D, and F) show the behavior of the system for the same parameter values as the corresponding panels on the left but when TGF-β concentration is increased slowly, (B) inset.
(A and B) Same parameter values as in Figure 5A with the exception that the constitutive and ligand-induced degradation rates have been decreased and increased by a factor three, respectively: kcd = (3 × 36 min)−1; ligand-induced degradation klid = (4/3 min)−1.
(C and D) Same parameter values as in Figure 5A. Figure in (C) is exactly the same as Figure 5A.
(E and F) Same parameter values as in Figure 5A with the exception that the constitutive and ligand-induced degradation rates have been increased and decreased by a factor three, respectively: kcd = (36/3 min)−1; ligand-induced degradation klid = (3 × 4 min)−1.