Long-Range Periodic Patterns in Microbial Genomes Indicate Significant Multi-Scale Chromosomal Organization
Figure 2
Generality of Chromosome Position-Dependent Patterns in Sequence Properties for 163 Prokaryotic Chromosomes
Continuous wavelet scalograms were computed for most prokaryotic chromosomes sequenced through January 2005 to identify patterns in CAI per gene (A), fractional gene density per kilobase (B), and GC/AT content per kilobase (C). The colored portions of the scalogram indicate significant periodic patterns (FDR < 5%). The degree of patterning for each prokaryotic sequence and each parameter (called the fractional pattern strength) was taken as the percentage of the area of the scalogram containing significant patterns. The first column shows the scalograms for the maximally patterned chromosome found for each sequence property. For reference, the second column shows these scalograms for E. coli K-12 MG1655. The third column shows the rank-ordered fractional pattern strengths for the 163 sequenced prokaryotic chromosomes that were analyzed, with E. coli indicated relative to the other chromosomes on each plot.