Structural Evolution of the Protein Kinase–Like Superfamily
Figure 6
Conventional Distance-Based Phylogenetic Tree of the Kinase-Like Superfamily, Based Only on the Sequence Alignment from Figure 3
This tree did not explicitly incorporate structural information, and is provided for purposes of comparison with the Bayesian tree presented in Figure 4. Structures are labeled by their PDB IDs, followed by the abbreviated name of the structure. The AKs are highlighted by orange ovals. Bootstrap values are provided for major branches. Some branches are too short for values to fit; these are marked with red letters that correspond to the following values: a, 199; b, 170; c, 101; d, 141. Branches highlighted in gray were not supported by bootstrap values above 500, and should be considered speculative (if based only on this tree data) [57,58]. Many of the core relationships within the superfamily cannot be resolved with confidence using the conventional sequence-based approach.