Comparative Genomics and Disorder Prediction Identify Biologically Relevant SH3 Protein Interactions
Figure 6
Predictions of S. cerevisiae SH3 Interactions
We considered that a potential target consensus sequence, found by pattern matching, in an S. cerevisiae protein would be biologically relevant if it was within an unstructured region of the S. cerevisiae protein and also conserved in four of the seven comparison genomes used. (C. glabrata, K. lactis, C. albicans, D. hansenii, Y. lipolytica, N. crassa, and Sch. pombe). Red lines indicate the interactions for which we found some experimental evidence in protein interaction databases [59–61]; thin black lines indicate interactions between proteins that are labeled as locating to different compartments; thick black lines indicate interactions for which we found no evidence. There were two S. cerevisiae SH3 domains for which we could not predict any interaction because of the stringency applied. A complete list of the interactions with function, localization, and binding positions is given in Table S4.