Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

• Ping Xu ,

  Contributed equally to this work with: Ping Xu, Zile Luo, Xi Chen

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliations BGI Research, Chongqing, China, BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China

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• Zile Luo ,

  Contributed equally to this work with: Ping Xu, Zile Luo, Xi Chen

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations BGI Research, Chongqing, China, College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China

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• Xi Chen ,

  Contributed equally to this work with: Ping Xu, Zile Luo, Xi Chen

  Roles Funding acquisition, Investigation, Validation

  Affiliations BGI Research, Chongqing, China, State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China

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• Zhongyang Yuan,

  Roles Formal analysis

  Affiliation BGI Research, Chongqing, China

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• Le Cheng,

  Roles Supervision

  Affiliation BGI Research, Kunming, China

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• Yi Yang,

  Roles Supervision

  Affiliation BGI Research, Kunming, China

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• Hongcheng Lin ,

  Roles Funding acquisition, Supervision, Writing – review & editing, Conceptualization

  * E-mail: lhcheng@mail.sysu.edu.cn (HL); 1153776174@qq.com (QZ); pengf.qin@outlook.com (PQ)

  Affiliations Department of General Surgery (Department of Coloproctology), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

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• Qiong Zhang ,

  Roles Supervision, Writing – review & editing, Conceptualization

  * E-mail: lhcheng@mail.sysu.edu.cn (HL); 1153776174@qq.com (QZ); pengf.qin@outlook.com (PQ)

  Affiliation Department of Obstetrics and Reproductive Medicine, Affiliated Hospital of Yunnan University, Kunming, Yunnan, China

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• Pengfei Qin

  Roles Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing, Conceptualization

  * E-mail: lhcheng@mail.sysu.edu.cn (HL); 1153776174@qq.com (QZ); pengf.qin@outlook.com (PQ)

  Affiliations BGI Research, Chongqing, China, State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen, China, Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, Henan, China

  https://orcid.org/0009-0009-0101-343X

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