iDCF: Interpretable deconvolution of cell fractions via biologically-informed deep learning using scRNA-seq data

• Hongjiang Guo ,

  Contributed equally to this work with: Hongjiang Guo, Tingfang Wu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Tingfang Wu ,

  Contributed equally to this work with: Hongjiang Guo, Tingfang Wu

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: tfwu@suda.edu.cn (TW); ljquan@suda.edu.cn (LQ); huangml@suda.edu.cn (MH); qiang@suda.edu.cn (QL)

  Affiliations School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China, Biomedical Basic Research Center (BBRC) of Jiangsu, Suzhou, Jiangsu, China, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Soochow University, Suzhou, Jiangsu, China

  https://orcid.org/0000-0001-8137-2436

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• Wenzheng Wang,

  Roles Data curation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Yelu Jiang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Geng Li,

  Roles Software, Validation, Writing – review & editing

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Liangpeng Nie,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Yunhua Jia,

  Roles Software, Validation, Writing – review & editing

  Affiliation School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China

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• Lijun Quan ,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: tfwu@suda.edu.cn (TW); ljquan@suda.edu.cn (LQ); huangml@suda.edu.cn (MH); qiang@suda.edu.cn (QL)

  Affiliations School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Soochow University, Suzhou, Jiangsu, China

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• Moli Huang ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: tfwu@suda.edu.cn (TW); ljquan@suda.edu.cn (LQ); huangml@suda.edu.cn (MH); qiang@suda.edu.cn (QL)

  Affiliation MOE Key Laboratory of Geriatric Diseases and Immunology, School of Basic Medical Sciences, Suzhou Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, China

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• Qiang Lyu

  Roles Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: tfwu@suda.edu.cn (TW); ljquan@suda.edu.cn (LQ); huangml@suda.edu.cn (MH); qiang@suda.edu.cn (QL)

  Affiliations School of Computer Science and Technology, Soochow University, Suzhou, Jiangsu, China, Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, Soochow University, Suzhou, Jiangsu, China

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