Multiscale modeling of T cell exhaustion: A mathematical framework integrating continuous dynamics with spatial heterogeneity

• Chenghang Li,

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Mathematical Sciences, Tiangong University, Tianjin, China

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• Yuhong Zhang,

  Roles Software, Validation, Visualization

  Affiliation School of Software, Tiangong University, Tianjin, China

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• Xue Liu,

  Roles Data curation, Software, Visualization

  Affiliation School of Mathematics, Shandong University, Jinan, China

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• Yipu Qu,

  Roles Software, Visualization

  Affiliation School of Mathematical Sciences, Tiangong University, Tianjin, China

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• Xiulan Lai ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: xiulanlai@ruc.edu.cn (XL); jzlei@tiangong.edu.cn (JL)

  Affiliation School of Mathematics, Renmin University of China, Beijing, China

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• Jinzhi Lei

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: xiulanlai@ruc.edu.cn (XL); jzlei@tiangong.edu.cn (JL)

  Affiliations School of Mathematical Sciences, Tiangong University, Tianjin, China, Center for Applied Mathematics, Tiangong University, Tianjin, China

  https://orcid.org/0000-0002-2670-6760

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