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Open Access
Peer-reviewed
Research Article
Deep learning-supported image quantification of epithelial cell shapes and its application to polycystic kidney disease
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Johannes Jahn ,
Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
* E-mail: johannes.jahn@uniklinik-freiburg.de (JJ); michael.koettgen@uniklinik-freiburg.de (MK)
Affiliations Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany, Department of Radiology, Medical Center – University of Freiburg, Faculty of Medicine – University of Freiburg, Freiburg, Germany
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Alexis Hofherr,
Roles Conceptualization, Methodology, Software, Supervision
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Clara Consoli,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Berenike Fajen,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Rebekka Goll,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Greta Theresa Liedtke,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Adrian Boehm,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Friederike Selbach,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Paul Christoph Zeisler,
Roles Data curation, Investigation
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Vanessa Weichselberger,
Roles Data curation, Investigation
Affiliations Hilde-Mangold-Haus, University of Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany, CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany
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Anne-Kathrin Classen,
Roles Data curation, Supervision, Writing – review & editing
Affiliations Hilde-Mangold-Haus, University of Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany, CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany
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Lukas Westermann,
Roles Data curation, Methodology, Supervision, Writing – review & editing
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Tilman Busch,
Roles Investigation, Supervision
Affiliation Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
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Michael Köttgen
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: johannes.jahn@uniklinik-freiburg.de (JJ); michael.koettgen@uniklinik-freiburg.de (MK)
Affiliations Department of Medicine IV-Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany, CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany
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Deep learning-supported image quantification of epithelial cell shapes and its application to polycystic kidney disease
- Johannes Jahn,
- Alexis Hofherr,
- Clara Consoli,
- Berenike Fajen,
- Rebekka Goll,
- Greta Theresa Liedtke,
- Adrian Boehm,
- Friederike Selbach,
- Paul Christoph Zeisler,
- Vanessa Weichselberger
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- Published: August 3, 2026
- https://doi.org/10.1371/journal.pcbi.1014614