Body surface potential driven personalisation of electrophysiological digital twins in hypertrophic cardiomyopathy

Shambhavi Malik; Ludovica Cicci; Abdul Qayyum; Rahul Ghelani; Ji-jian Chow; Jagdeep Singh Mohal; Zachary I. Whinnett; Amanda Varnava; Gernot Plank; Prapa Kanagaratnam; Steven A. Niederer

doi:10.1371/journal.pcbi.1014555

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Open Access

Peer-reviewed

Research Article

Body surface potential driven personalisation of electrophysiological digital twins in hypertrophic cardiomyopathy

Shambhavi Malik ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: s.malik23@imperial.ac.uk

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom

https://orcid.org/0000-0003-1374-4765

⨯
Ludovica Cicci,

Roles Conceptualization, Data curation, Methodology, Software, Supervision, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Abdul Qayyum,

Roles Data curation, Methodology, Software, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Rahul Ghelani,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Ji-jian Chow,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Jagdeep Singh Mohal,

Roles Data curation, Investigation, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Zachary I. Whinnett,

Roles Data curation, Writing – review & editing

Affiliation National Heart and Lung Institute, Imperial College London, London, United Kingdom
⨯
Amanda Varnava,

Roles Data curation, Writing – review & editing

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Gernot Plank,

Roles Data curation, Methodology, Software, Writing – review & editing

Affiliation Medical University of Graz, Graz, Austria
⨯
Prapa Kanagaratnam,

Roles Data curation, Writing – review & editing

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom
⨯
Steven A. Niederer

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations National Heart and Lung Institute, Imperial College London, London, United Kingdom, The Alan Turing Institute, London, United Kingdom
⨯

Body surface potential driven personalisation of electrophysiological digital twins in hypertrophic cardiomyopathy

Shambhavi Malik,
Ludovica Cicci,
Abdul Qayyum,
Rahul Ghelani,
Ji-jian Chow,
Jagdeep Singh Mohal,
Zachary I. Whinnett,
Amanda Varnava,
Gernot Plank,
Prapa Kanagaratnam

Published: July 27, 2026
https://doi.org/10.1371/journal.pcbi.1014555

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Twins
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