In silico clinical trials of BiTE expression by oncolytic viruses reveal the impact of patient heterogeneity on dosage protocol

• Adrianne L. Jenner ,

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

  * E-mail: adrianne.jenner@qut.edu.au

  Affiliation School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

  https://orcid.org/0000-0001-9103-7092

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• Robyn P. Araujo,

  Roles Methodology, Writing – review & editing

  Affiliation School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia

  https://orcid.org/0000-0002-3360-2214

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• Noa L. Levi,

  Roles Formal analysis, Writing – original draft

  Affiliation School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia

  https://orcid.org/0000-0003-2635-1426

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• Guy Ungerechts,

  Roles Resources, Writing – review & editing

  Affiliations Clinical Cooperation Unit “Virotherapy”, German Cancer Research Center (DKFZ), Heidelberg, Germany, National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany, Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany

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• Christine E. Engeland,

  Roles Conceptualization, Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Experimental Hematology and Immunotherapy, Department of Hematology, Hemostaseology, Cellular Therapy and Infectious Diseases, Faculty of Medicine and Leipzig University Hospital, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany

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• Johannes P. W. Heidbuechel

  Roles Conceptualization, Data curation, Investigation, Resources, Writing – original draft, Writing – review & editing

  Affiliations Clinical Cooperation Unit “Virotherapy”, German Cancer Research Center (DKFZ), Heidelberg, Germany, National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany

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