CLDN18.2 antibody design with protein language models: A deep learning optimization framework

• Tao Qu ,

  Contributed equally to this work with: Tao Qu, Lingyan Yuan

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliations NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, Gansu, China, The Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou, Gansu, China

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• Lingyan Yuan ,

  Contributed equally to this work with: Tao Qu, Lingyan Yuan

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: caialon@163.com (HC), yuanly21@gdlhz.ac.cn (LY)

  Affiliation Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, China

  https://orcid.org/0000-0002-3786-2849

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• Weiran Cui,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Fujian Institute of Research on the Structure, Chinese Academy of Sciences, Fuzhou, China

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• Jiatian Tang,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliation Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center of Gastrointestinal Cancer, Peking University Cancer Hospital & Institute, Beijing, China

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• Zhitong Bing,

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Computational Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China

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• Xianghong Xu,

  Roles Project administration, Resources, Supervision

  Affiliations NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, Gansu, China, The Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou, Gansu, China

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• Jizheng Duan,

  Roles Data curation, Methodology, Resources

  Affiliation Department of Computational Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China

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• Qiong Yang,

  Roles Investigation, Methodology, Resources

  Affiliation Department of Computational Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China

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• Hui Cai

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  * E-mail: caialon@163.com (HC), yuanly21@gdlhz.ac.cn (LY)

  Affiliation NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, Gansu, China

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