Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury

Alda Sabalic; Victoria Moiseeva; Andres Cisneros; Oleg Deryagin; Eusebio Perdiguero; Pura Muñoz-Cánoves; Jordi Garcia-Ojalvo

doi:10.1371/journal.pcbi.1014429

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Open Access

Peer-reviewed

Research Article

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury

Alda Sabalic,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Victoria Moiseeva,

Roles Conceptualization, Data curation, Methodology, Resources, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Andres Cisneros,

Roles Conceptualization, Data curation, Methodology, Resources, Writing – review & editing

Affiliations Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Altos Labs, Inc., San Diego Institute of Science, San Diego, California, United States of America
⨯
Oleg Deryagin,

Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Eusebio Perdiguero,

Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Altos Labs, Inc., San Diego Institute of Science, San Diego, California, United States of America
⨯
Pura Muñoz-Cánoves,

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain, Altos Labs, Inc., San Diego Institute of Science, San Diego, California, United States of America
⨯
Jordi Garcia-Ojalvo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: jordi.g.ojalvo@upf.edu

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain

https://orcid.org/0000-0002-3716-7520

⨯

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury

Alda Sabalic,
Victoria Moiseeva,
Andres Cisneros,
Oleg Deryagin,
Eusebio Perdiguero,
Pura Muñoz-Cánoves,
Jordi Garcia-Ojalvo

Published: June 22, 2026
https://doi.org/10.1371/journal.pcbi.1014429

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