Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach

Cillian Hourican; Geeske Peeters; René J. F. Melis; Almar Kok; Natasja M. van Schoor; Sandra Wezeman; Mike Lees; Marcel G. M. Olde Rikkert; Rick Quax

doi:10.1371/journal.pcbi.1014386

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Open Access

Peer-reviewed

Research Article

Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach

Cillian Hourican ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: c.j.hourican@uva.nl

Affiliation Computational Science Lab, Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands

https://orcid.org/0009-0002-3161-0736

⨯
Geeske Peeters,

Roles Supervision, Validation, Writing – review & editing

Affiliations Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboudumc Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
René J. F. Melis,

Roles Validation, Writing – review & editing

Affiliation Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Almar Kok,

Roles Data curation, Resources, Writing – review & editing

Affiliations Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands
⨯
Natasja M. van Schoor,

Roles Data curation, Resources, Writing – review & editing

Affiliations Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands, Amsterdam Public Health Research Institute, Aging and Later Life, Amsterdam, The Netherlands
⨯
Sandra Wezeman,

Roles Validation, Writing – review & editing

Affiliation Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Mike Lees,

Roles Writing – review & editing

Affiliations Computational Science Lab, Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands, Institute for Advanced Study, Amsterdam, The Netherlands
⨯
Marcel G. M. Olde Rikkert,

Roles Validation, Writing – review & editing

Affiliations Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Radboudumc Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Rick Quax

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Computational Science Lab, Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands, Institute for Advanced Study, Amsterdam, The Netherlands
⨯

Interpreting higher-order dependence in multimorbidity using cohort data: A partial information decomposition approach

Cillian Hourican,
Geeske Peeters,
René J. F. Melis,
Almar Kok,
Natasja M. van Schoor,
Sandra Wezeman,
Mike Lees,
Marcel G. M. Olde Rikkert,
Rick Quax

Published: June 10, 2026
https://doi.org/10.1371/journal.pcbi.1014386

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