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Open Access
Peer-reviewed
Research Article
Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework
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Zhuoqi Zheng ,
Contributed equally to this work with: Zhuoqi Zheng, Bo Zhang
Roles Investigation, Methodology, Resources, Validation, Writing – original draft, Data curation
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Bo Zhang ,
Contributed equally to this work with: Zhuoqi Zheng, Bo Zhang
Roles Methodology, Data curation
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Bozitao Zhong,
Roles Methodology
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Jinyu Yu,
Roles Methodology
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Kexin Liu,
Roles Methodology
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Zhengxin Li,
Roles Methodology
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Junjie Zhu,
Roles Methodology
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Ting Wei ,
Roles Investigation, Supervision
* E-mail: weitinging@sjtu.edu.cn (TW); haifengchen@sjtu.edu.cn (H-FC)
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Hai-Feng Chen
Roles Conceptualization, Funding acquisition, Supervision
* E-mail: weitinging@sjtu.edu.cn (TW); haifengchen@sjtu.edu.cn (H-FC)
Affiliation State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
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Scaffold-Lab: Critical evaluation and ranking of protein backbone generation methods in a unified framework
- Zhuoqi Zheng,
- Bo Zhang,
- Bozitao Zhong,
- Jinyu Yu,
- Kexin Liu,
- Zhengxin Li,
- Junjie Zhu,
- Ting Wei,
- Hai-Feng Chen
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- Published: May 22, 2026
- https://doi.org/10.1371/journal.pcbi.1014290
- See the preprint